Absolutely! The more Himalayan salt lamps or candle holders you have in the space will release a greater amount of negative ions. The higher the concentration of negative ions, the more benefits will be experienced within that space.
Experiment with your area and how different set ups make you feel. For instance, place the candle holders together to maximize efficiency or place them in opposite corners of the room. The space that is surrounded by the soft glow experiences the greatest concentration of negative ions.
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